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Home Page > Products by Alphabet > LEVOTOP 500 mg
   
 
 
  Brand name: LEVOTOP 500 mg  
  Formula: Coated Tablets    
  Categories: Antibiotics  
  Code: 13-10  
  Composition:

Each film coated tablet contains:
Levofloxacine 500 mg (As Levofloxacin Hemihydrate).

 
 
  Detailed Information:

INDICATIONS AND USAGE:
LEVOTOP Tablets are indicated for the treatment of adults (≥ 18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed below:
- Nosocomial Pneumonia
- Community-Acquired Pneumonia: 7-14 day Treatment Regimen
- Community-Acquired Pneumonia: 5-day Treatment Regimen
- Acute Bacterial Sinusitis: 5-day and 10-14 day Treatment Regimens
- Acute Bacterial Exacerbation of Chronic Bronchitis
- Complicated Skin and Skin Structure Infections
- Uncomplicated Skin and Skin Structure Infections
- Chronic Bacterial Prostatitis
- Complicated Urinary Tract Infections: 5-day Treatment Regimen
- Complicated Urinary Tract Infections: 10-day Treatment Regimen
- Acute Pyelonephritis: 5 or 10-day Treatment Regimen
- Uncomplicated Urinary Tract Infections
- Inhalational Anthrax (Post-Exposure)
- Drug Interaction with Chelation Agents: Antacids, Sucralfate, Metal Cations, Multivitamins.
CONTRAINDICATIONS:
- Hypersensitivity to one of the components .
- Pregnancy and lactation
- Infants and children
SIDE EFFECTS:
Nausea, diarrhea, abdominal pain, dyspepsia, dizziness, headache, anxiety, fatigue, nervousness, pruritus, genital moniliasis and rarely abnormal renal function.
DOSAGE AND ADMINISTRATION:
Dosage Adjustment in Adults with Renal Impairment:
Administer LEVOTOP with caution in the presence of renal insufficiency. Careful clinical observation and appropriate laboratory studies should be performed prior to and during therapy since elimination of levofloxacin may be reduced.
No adjustment is necessary for patients with a creatinine clearance ≥ 50 mL/min.
In patients with impaired renal function (creatinine clearance < 50 mL/min), adjustment of the dosage regimen is necessary to avoid the accumulation of levofloxacin due to decreased clearance.

Dosage Adjustment in Patients with Renal Impairment (creatinine clearance < 50 mL/min):

- Dosage in Normal                   750 mg
Renal Function
Every 24 hours

Creatinine Clearance 20          750 mg every 48 hours
to 49 mL/min

Creatinine Clearance 10          750 mg initial dose, then 500
19 mL/min                                mg every 48 hours

Hemodialysis or Chronic           750 mg initial dose, then 500
Ambulatory Peritoneal              mg every 48 hours
Dialysis (CAPD)
 
- Dosage in Normal                   500 mg
Renal Function
Every 24 hours

Creatinine Clearance 20           500 mg initial dose, then
to 49 mL/min                            250 mg every 24 hours

Creatinine Clearance 10           500 mg initial dose, then 250
19 mL/min                                 mg every 48 hours

Hemodialysis or Chronic           500 mg initial dose, then 250
Ambulatory Peritoneal              mg every 48 hours
Dialysis (CAPD)

- Dosage in Normal                   250 mg
Renal Function
Every 24 hours

Creatinine Clearance 20           No dosage adjustment required
to 49 mL/min   

Creatinine Clearance 10          250 mg every 48 hours. If treating
19 mL/min                                uncomplicated UTI,  then no dosage 
                                                   adjustment is required.

Hemodialysis or Chronic
          No information on dosing
Ambulatory Peritoneal             adjustment is available
Dialysis (CAPD)
 
HOW SUPPLIED:
Boxes of 10 F.C.tab.

 
   
 
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