MOTABAR is used as an antiemetic for the short-term treatment of nausea and vomiting of various aetiologies, including that associated with cancer therapy, and nausea and vomiting associated with levodopa or bromocriptine therapy for Parkinsonism.
Domperidone is also used for its prokinetic actions in dyspepsia and has been tried in diabetic gastroparesis and there were some responses. It is given with Paracetamol in the symptomatic treatment of migraine.
- Hypersensitivity to domperidone or to one of the excipients.
- Hypophyseal prolactin tumor.
- MOTABAR should not be used when gastric motivation may be noticed, because it may cause gastrointestinal hemorrhage, mechanical obstruction or perforation.
Plasma-prolactin concentrations may be increased which may lead to galactorrhoea or gynaecomastia. There have been reports of reduced libido, and rashes and other allergic reactions. Domperidone does not readily cross the blood-brain barrier and the incidence of central effects such as extrapyramidal reactions or drowsiness may be lower than with metoclopramide; however, there have been reports of dystonic reactions.
DOSAGE & ADMINISTRATION:
For the treatment of nausea and vomiting
Adults: 1-2 tablets 3 or 4 times daily up to a maximum daily dose of 8 tablets.
Children: 250-500 mcg/kg 3 to 4 times daily, up to a maximum daily dose of 2.4 mg/kg and should not exceed a total of 80 mg daily.
For the symptomatic treatment of non-ulcer dyspepsia
Adults: 1 tablet 3 times daily before meals and at night. Depending on clinical response the dose may be increased to 2 tablets if necessary.
An initial course of treatment should not normally exceed 2 to 4 weeks.
Adults: 2 tablets may be taken up to every 4 hours, with paracetamol as required, up to a maximum of 4 doses in 24 hours.
Boxes of 20 tablets.