The use of this medication is limited to the infections of organisms susceptible to Ampicillin, especially in their manifestations which include:
- Sinusitis, tonsillitis
- Renal and urogenital
- Gastrointestinal and biliary
- Septicemic and endocardial
It is suitable to take in consideration the official recommendations concerning the use of the appropriate antibacterial.
- Allergy to penicillins.
- Infections caused by herpes group virus especially the infectious mononucleosis, (increase in the risk of cutaneous accidents).
As with all penicillins:
- Allergic manifestations: notably urticaria, eosinophilia, Quincke’s edema, respiratory uneasiness, exceptionally anaphylactic shock.
- Maculopapular skin rash of allergic origin, rare cases of exfoliative dermatitis and erythema multiforme have been reported.
- Gastrointestinal disorders: nausea, vomiting, diarrhea, candidiasis, glossitis, stomatitis.
Other manifestations have been reported rarely:
- Moderate and transitory increase in serum transaminases.
- Anemia, leukopenia, reversible thrombocytopenia.
- Acute interstitial nephritis.
- Some cases of pseudomembranous enterocolitis after administration of Ampicillin have been reported.
The administration of large doses of betalactames especially in renal insufficiency may cause metabolic encephalopathy. (Disorder of the conscience, abnormal movements, and convulsive seizures).
DOSAGE AND ADMINISTRATION:
Adults and children weighing over 20 kg:
For genitourinary or gastrointestinal tract infections other than gonorrhea in men and women: the usual dose is 500 mg 4 times daily (500 mg every 6 hours); larger doses may be required for severe or chronic infections.
For the treatment of gonorrhea in men and women: a single oral dose of 3.5 grams of ampicillin with 1 gram of probenecid administered simultaneously is recommended. Physicians are cautioned to use no less than the above recommended dosage for the treatment of gonorrhea. Follow up cultures should be obtained from the original site(s) of infection 7 to 14 days after therapy. In women, it is also desirable to obtain culture test-of-cure from both the endocervical and the anal canals. Prolonged intensive therapy is needed for complications such as prostatitis and epididymitis.
For respiratory infections: the usual dose is 250 mg 4 times daily (250 mg every 6 hours).
Dosage Adjustment is recommended in renal insufficiency.
- Creatinine clearance 30 to 60 ml/min: 2 to 4 g/ daily; the total daily dose should not exceed 4 g.
- Creatinine clearance 10 to 30 ml/min: 1 g then 500 mg every 12 hours.
- Creatinine clearance < 10 ml/min: 1 g then 500 mg every 24 hours.
These doses can be insufficient in severe infections probably meningeal; it’s advised to control serum levels of Ampicillin.
AMPICILLIN BARAKAT Capsules should be taken with a full glass of water, one-half hour before or two hours after meals.
Children weighing 20 kg or less:
For genitourinary or gastrointestinal tract infections: the usual dose is 100 mg/kg/day total, administered 4 times daily in equally divided and spaced doses.
For respiratory infections: the usual dose is 50 mg/kg/day total, administered in equally divided and spaced doses three to four times daily (i.e., every 8 to 6 hours).
Doses for children should not exceed recommended for adults.
Carton box of 20 capsules.