BIOLORIC is used for treatment of:
- Hyperuricemia associated with gout, urate nephropathy caused by urea mono sodium, during cancer chemo & radio therapy.
- BIOLORIC is also used in the management of renal calculi due to the deposition of calcium oxalate.
- It should not be used with patients who have developed hypersensitivity to the drug.
- BIOLORIC is used with caution during pregnancy and lactation (under medical supervision).
- Acute attack of gout.
BIOLORIC may cause nausea, vomiting, diarrhea, skin rash, headache, and may cause leucopenia.
- Treatment should be stopped if any skin reactions or other signs of hypersensitivity develop.
- BIOLORIC should be used with caution in patients suffering from renal or hepatic impairment.
- BIOLORIC should be used with caution in patients suffering from hypertension and diabetes mellitus.
- BIOLORIC should be used with care when administered with Ampicillin or Thiazide diuretics. It may develop an increase in hypersensitivity reactions.
- BIOLORIC enhances the activity of captopril, coumarine derivatives, and theophylline.
DOSAGE & ADMINISTRATION:
The starting dose of allopurinol is 100 mg daily gradually increased by 100 mg at weekly intervals.
In case of mild to moderate gout: 100-300 mg daily.
In case of moderately severe tophaceous gout: 600 mg daily.
The maximum daily dose should not exceed 900 mg; the single dose should not exceed 300 mg.
When used for the prevention of uric acid nephropathy associated with cancer therapy:
600-900 mg daily generally for 2 or 3 days and starting before the cancer treatment.
The main use of allopurinol in children is for hyperuricaemia associated with cancer or cancer chemotherapy or with enzyme disorders:
For children under 6 years of age: 150 mg.
For children 6-10 years of age: 300 mg, adjusted if necessary after 48 hours.
Note: BIOLORIC is best taken after food, and patients should maintain an adequate fluids intake (about 2 liters daily) to prevent renal calculi formation.
Boxes of 50 tablets.