INDICATIONS AND USAGE:
NORMOTIC is indicated in the treatment of hypertension.
NORMOTIC is contraindicated in patients with: sinus bradycardia; heart block greater than first degree; cardiogenic shock; overt cardiac failure; anuria; hypersensitivity to this product or to sulfonamide-derived drugs.
NORMOTIC is usually well tolerated in properly selected patients. Most adverse effects have been mild and transient.
CARDIOVASCULAR: bradycardia, cold extremities, postural hypotension, and leg pain.
CENTRAL NERVOUS SYSTEM/NEUROMUSCULAR: dizziness, vertigo, light-headedness, tiredness, fatigue, lethargy, drowsiness, depression, dreaming.
GASTROINTESTINAL: diarrhea, nausea.
RESPIRATORY: wheezing, dyspnea.
Body As A Whole: weakness; Digestive: pancreatitis, jaundice (intrahepatic cholestatic jaundice), sialadenitis, cramping, gastric irritation; Hematologic: aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia; Hypersensitivity: purpura, photosensitivity, urticaria, necrotizing angiitis (vasculitis and cutaneous vasculitis), fever, respiratory distress including pneumonitis and pulmonary edema, anaphylactic reactions; Metabolic: hyperglycemia, glycosuria, hyperuricemia; Musculoskeletal: muscle spasm; Nervous System/Psychiatric: restlessness; Renal: renal failure, renal dysfunction, interstitial nephritis; Skin: erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis; Special Senses: transient blurred vision, xanthopsia.
DOSAGE AND ADMINISTRATION:
DOSAGE MUST BE INDIVIDUALIZED.
One tablet daily or as prescribed by the physician.
When necessary, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure.
Since atenolol is excreted via the kidneys, dosage should be adjusted in cases of severe impairment of renal function. No significant accumulation of atenolol occurs until creatinine clearance falls below 35 mL/min/1.73m 2 (normal range is 100-150 mL/min/1.73m 2); therefore, the following maximum dosages are recommended for patients with renal impairment.
Creatinine Clearance Atenolol Elimination
(mL/min/1.73m 2) Half-life (hrs) Maximum Dosage
15-35 16-27 50 mg daily
<15 >27 50 mg every other day
Boxes of 30 tables.