Description
Indications:
- Acute bacterial sinusitis
- Acute otitis media
- Acute streptococcal tonsillitis and pharyngitis
- Acute exacerbations of chronic bronchitis
- Community acquired pneumonia
- Acute cystitis
- Asymptomatic bacteriuria in pregnancy
- Acute pyelonephritis
- Typhoid and paratyphoid fever
- Dental abscess with spreading cellulitis
- Prosthetic joint infections
- Helicobacter pylori eradication
- Lyme disease
- Prophylaxis of endocarditis
Contraindications:
- Hypersensitivity to any of the drug components
- History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam)
Adverse Effects:
Diarrhea, nausea and skin rash
Dosage and administration:
For adults and children ≥ 40 kg
| Indication | Doses |
| Acute bacterial sinusitis | 250 mg to 500 g every 8 hours or 750 mg to 1 g every 12 hours
For severe infections: 750 mg to 1 g every 8 hours Acute cystitis may be treated with 3 g twice daily for one day |
| Asymptomatic bacteriuria in pregnancy | |
| Acute pyelonephritis | |
| Dental abscess with spreading cellulitis | |
| Acute cystitis | |
| Acute otitis media | 500 mg every 8 hours, 750 mg to 1 g every 12 hours
For severe infections 750 mg to 1 g every 8 hours for 10 days |
| Acute streptococcal tonsillitis and pharyngitis | |
| Acute exacerbations of chronic bronchitis | |
| Community acquired pneumonia | 500 mg to 1 g every 8 hours |
| Typhoid and paratyphoid fever | 500 mg to 2 g every 8 hours |
| Prosthetic joint infections | 500 mg to 1 g every 8 hours |
| Prophylaxis of endocarditis | 2 g orally, single dose 30 to 60 minutes before procedure |
| Helicobacter pylori eradication | 750 mg to 1 g twice daily in combination with a proton pump inhibitor (e.g. omeprazole, lansoprazole) and another antibiotic (e.g. clarithromycin, metronidazole) for 7 days |
| Lyme disease | Early stage: 500 mg to 1 g every 8 hours up to a maximum of 4 g/day in divided doses for 14 days (10 to 21 days)
Late stage (systemic involvement): 500 mg to 2 g every 8 hours up to a maximum of 6 g/day in divided doses for 10 to 30 days |
For children < 40 kg:
| Indication | Dose |
| Acute bacterial sinusitis | 20 to 90 mg/kg/day in divided doses
(Twice daily dosing regimens should only be considered when the dose is in the upper range) |
| Acute otitis media | |
| Community acquired pneumonia | |
| Acute cystitis | |
| Acute pyelonephritis | |
| Dental abscess with spreading cellulitis | |
| Acute streptococcal tonsillitis and pharyngitis | 40 to 90 mg/kg/day in divided doses
(Twice daily dosing regimens should only be considered when the dose is in the upper range) |
| Typhoid and paratyphoid fever | 100 mg/kg/day in three divided doses |
| Prophylaxis of endocarditis | 50 mg/kg orally, single dose 30 to 60 minutes before procedure |
| Lyme disease | Early stage: 25 to 50 mg/kg/day in three divided doses for 10 to 21 days
Late stage (systemic involvement): 100 mg/kg/day in three divided doses for 10 to 30 days |
Renal impairment:
| GFR (ml/min) | Adults and children ≥ 40 kg | Children < 40 kg
(In the majority of cases, parenteral therapy is preferred |
| greater than 30 | no adjustment necessary | no adjustment necessary |
| 10 to 30 | maximum 500 mg twice daily | 15 mg/kg given twice daily
(maximum 500 mg twice daily) |
| Less than 30 | Maximum 500 mg/day. | 15 mg/kg given as a single
daily dose (maximum 500 mg |
In patients receiving hemodialysis
| Hemodialysis | |
| Adults and children ≥ 40 kg | 15 mg/kg/day given as a single daily dose.
Prior to hemodialysis one additional dose of 15 mg/kg should be administered. In order to restore circulating drug levels, another dose of 15 mg/kg should be administered after hemodialysis. |
How Supplied:
- AMOXICILLIN BARAKAT Powder for Oral Suspension: Bottles of 60 ml, 100 ml.
- AMOXICILLIN BARAKAT Capsules: Boxes of 20 capsules.
