Bisacodyl is a contact stimulant laxative, administered either orally or rectally, which acts directly on the colonic mucosa to produce normal peristalsis. Bisacodyl is very poorly absorbed, if at all, in the small intestine following oral administration, or the large intestine following rectal administration. On contact with mucosa or submucosal plexus of the large intestine, Bisacodyl stimulates sensory nerve endings to produce parasympathetic reflexes resulting in increased peristaltic contractions of the colon. It has also been shown to promote fluid and ion accumulation in the colon, which increases the laxative effect. A bowel movement is usually produced approximately 6 hours after oral administration and approximately 15 minutes to 1 hour after rectal administration providing satisfactory cleaning of the bowel which may under certain circumstances obviate the need for colonic irritation.
Barkalaxine is useful in all kinds of constipation:
- Chronic constipation in aged patients.
- Patients with constipation resulting from prolonged bed-lying.
- Pre and post surgical operations.
- Preparation for barium enema.
- Preparation of colon and procto-sigmoid scopy.
Stimulant laxatives such as Bisacodyl are contraindicated in patients with acute surgical abdomen, appendicitis, rectal bleeding, gastroenteritis, or intestinal obstruction.
WARNINGS & PRECAUTIONS:
Use of Bisacodyl is not recommended when abdominal pain, nausea, or vomiting are present.
Long-term administration of Bisacodyl is not recommended in the treatment of chronic constipation. This product should not be used beyond 7 days unless deemed necessary.
Rectal bleeding or failure to have a bowel movement after Bisacodyl use may be indicated a serious condition. If this occurs the patient should discontinue use of the product.
This and all medications should be kept out of the reach of children.
Category B: Although no teratogenic effects have been detected in animals or in human infants following use of the drug during pregnancy, the manufacturers recommend that Bisacodyl, like other medicines, should not be used during pregnancy, especially the first trimester, unless the expected benefit is thought to outweigh any possible risk to the fetus.
The process of restoring normal bowel function by use of a laxative may result in some abdominal discomfort.
There are no specific antidotes that are required to be administered in the event of overdosage; however, supportive care may be required in order to prevent dehydration and/or electrolyte imbalance.
DOSAGE & ADMINISTRATION:
Adults and children 12 years of age and over:
2 tablets at bed time for an effect in the morning or half an hour before breakfast for an effect after 5 hours.
The dose may be increased up to 4 tablets if necessary.
Children 6-12 years of age:
1 tablet daily.
– Do not chew or crush the tablets.
– Do not administer tablets within 1 hour after taking milk or an antacid.
– It should not be given to children under 6 years.
Boxes of 30 enteric coated tablets.
Store the product at a temperature below 30°C.
Keep out of the reach of children, and away from sunlight.