Description
Properties:
Loperamide is an anti-diarrheal agent, it is a synthetic opioid analogue which inhibits gut motility and may also reduce gastrointestinal secretions
Indications:
Pyramide is used as an adjunct in the management of acute and chronic diarrheas.
Contraindications:
- Hypersensitivity to drug.
- Patients with dysentery or if constipation must be avoided.
- Infants and children under 4 years.
Side effects:
- May cause: abdominal pain, nausea, dry mouth, dizziness, skin rashes, paralytic ileus particularly in infants and young children.
- A toxic hypertrophy in large intestine.
- May causes breakdown in the central nervous system in overdoses.
- The drug should not taken for more than two days – except if the physician decides that.
- The drug should not be used in overdoses without the supervision of the physician who’ll give the correct decision.
- PYRAMIDE should be used with caution in young children.
- If the diarrhea still continues after continuous three days of treatment. A medical supervision and a medical decision is essential.
Precautions:
- Pyramide should be used with caution in patients with hepatic dysfunction, inflammatory bowel disease or pseudomembranous colitis.
- It should be used during pregnancy only if dearly needed.
- Pyramide should be used with caution during lactation
Dosage and administration:
Acute diarrhea
Adults: the initial dose is 4 mg followed by 2 mg after each loose stool to a maximum 16 mg daily. The usual daily dose is 6 to 8 mg.
Children 4-8 years: 1 mg four times daily up to 3 days. Children 9-12 years: 2 mg tour times daily up to 5 days.
Chronic diarrhea:
Adults: the usual initial dose is 4-8 mg daily in divided doses.
If no improvement has been observed after treatment with 16 mg daily for at least 10 days, further administration is unlikely to be of benefit
PRESENTATION:
Boxes of 20 Capsules.
