Description
PROPERTIES:
BARKATRIM is an antibacterial. It is a mixture of the sulphonamide Sulphamethoxazole with Trimethoprim in the proportions (5: 1).
The two antibiotics act synergistically to produce abacteriostatic action against a wide range of gram-positive and gram-negative bacteria.
BARKATRIM blocks two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria.
INDICATIONS:
- Respiratory tract infections: acute and chronic bronchitis, bronchiectasis, pneumonia, pharyngitis, sinusitis and otitis media.
- Urinary tract infections: acute and chronic cystitis, pylonephritis, urethritis and prostatitis.
CONTRAINDICATIONS:
- Hypersensitivity to sulphonamida.
- Patients with severe renal, hepatic or blood disorders and patients with documented megaloblastic anemia.
- Pregnancy and lactation.
- Prenatal and newborn infants during six weeks of life.
SIDE EFFECTS:
It may cause: nausea, vomiting, stomatitis, skin rashes, leukopenia, thrombocytopenia and jaundice.
PRECAUTIONS:
- Treatment should be discontinued immediately a rash appears because of the risk of severe allergic reaction.
- Adequate fluid intake is necessary to reduce the risk of crystalluria.
- Dosage should be reduced in renal impairment and elderly patients.
DRUG INTERACTIONS:
- BARKATRIM may increase the effects of warfarin, phenytoin and digoxin.
- BARKATRIM increases the hypoglycemic effect of sulphonylurin.
- Should not be given to patients with reduced CCPD.
DOSAGE AND ADMINISTRATION:
Adults:
- BARKATRIM: 2 tablets twice daily.
- BARKATRIM FORT: 1 tablet twice daily.
Children:
- 6 weeks to 5 months: 1 teaspoonful (2.5 ml) of BARKATRIM suspension twice daily.
- 6 months to 5 years: 1 spoonful (5 ml) of BARKATRIM suspension twice daily.
- 6 to 12 years: 2 spoonfuls (5 ml) of BARKATRIM suspension twice daily, or 1 spoonful ( 5 ml ) of BARKATRIM FORT suspension twice daily. Or 8mg/kg/day.
PRESENTATION:
BARKATRIM
- Carton box containing 20 tablets.
- Bottles of 100 ml suspension.
BARKATRIM FORT
- Carton box containing 10 tablets.
- Carton box containing 20 tablets.
- Bottles of 100 ml suspension.