Description
MECHANISM OF ACTION:
Nebivolol is a β-adrenergic receptor blocking agent.
The mechanism of action of the antihypertensive response of HYPOVOLOL has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity and (5) vasodilation and decreased peripheral vascular resistance.
Indications and usage:
Hypertension:
- HYPOVOLOL is indicated for the treatment of hypertension, to lower blood pressure.
- HYPOVOLOL may be used alone or in combination with other antihypertensive agents.
CONTRAINDICATIONS:
HYPOVOLOL is contraindicated in the following conditions:
- Severe bradycardia.
- Heart block greater than first degree.
- Patients with cardiogenic shock.
- Decompensated cardiac failure.
- Sick sinus syndrome (unless a permanent pacemaker is in place).
- Patients with severe hepatic impairment.
- Patients who are hypersensitive to any component of this product.
ADVERSE REACTIONS:
Bradycardia, diarrhea, nausea, fatigue, chest pain, peripheral edema, headache, dizziness, insomnia, dyspnea, rash, asthenia, abdominal pain, hypercholesterolemia, paraesthesia.
DOSAGE AND ADMINISTRATION:
Hypertension
Recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents. The dose can be increased at 2-week intervals up to 40 mg.
Renal Impairment:
In patients with severe renal impairment (ClCr less than 30 mL/min) the recommended initial dose is 2.5 mg once daily
Hepatic Impairment:
In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily
HOW SUPPLIED:
Boxes of 30 tablets in blister.
